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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-3-7
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pubmed:abstractText |
To investigate the role of tumour-suppressor genes on the short arm of chromosome 3 in the mechanism of tumorigenesis in non-familial renal cell carcinoma, we analysed 55 paired blood-tumour DNA samples for allele loss on chromosome 3p and in the region of known or putative tumour-suppressor genes on chromosomes 5, 11, 17 and 22. Sixty-four per cent (35/55) of informative tumours showed loss of heterozygosity (LOH) of at least one locus on the short arm of chromosome 3, compared with only 13% at the p53 tumour-suppressor gene and 6% at 17q21. LOH at chromosome 5q21 and 22q was uncommon (2-3%). Detailed analysis of the regions of LOH on chromosome 3p suggested that, in addition to the VHL gene in chromosome 3p25-p26, mutations in one or more tumour-suppressor genes in chromosome 3p13-p24 may be involved in the pathogenesis of sporadic renal cell carcinoma (RCC). We also confirmed previous suggestions that chromosome 3p allele loss is not a feature of papillary RCC (P < 0.05).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1299377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1301149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1346080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1384667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1423316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1427857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1582882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1612588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1670999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1671754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1678685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1680799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1685475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1969617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-1997093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2011596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2274658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2276737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2352258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2738940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2885753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2894030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2894613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2921777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-2924296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-470981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-8094265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-8445612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-8493574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-8499917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297719-8499931
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
230-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8297719-Adult,
pubmed-meshheading:8297719-Aged,
pubmed-meshheading:8297719-Alleles,
pubmed-meshheading:8297719-Carcinoma, Renal Cell,
pubmed-meshheading:8297719-Chromosome Deletion,
pubmed-meshheading:8297719-Chromosome Mapping,
pubmed-meshheading:8297719-Chromosomes, Human, Pair 11,
pubmed-meshheading:8297719-Chromosomes, Human, Pair 22,
pubmed-meshheading:8297719-Chromosomes, Human, Pair 3,
pubmed-meshheading:8297719-Chromosomes, Human, Pair 5,
pubmed-meshheading:8297719-Female,
pubmed-meshheading:8297719-Heterozygote,
pubmed-meshheading:8297719-Humans,
pubmed-meshheading:8297719-Kidney Neoplasms,
pubmed-meshheading:8297719-Male,
pubmed-meshheading:8297719-Middle Aged
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pubmed:year |
1994
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pubmed:articleTitle |
Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22.
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pubmed:affiliation |
Department of Pathology, Cambridge University, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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