Thalamic lesions failed to affect the biosynthesis and storage of monoamines on the lesion side of the striatum of normal monkeys and of monkeys with ventromedial tegmental lesions. Distribution of cholinesterase in histochemical coronal, horizontal and sagittal sections suggest a strong chemical modulation of thalamic activity from basal ganglia and related structures projecting to neo- and paleostriatum. It is suggested that the thalamus is the second or third order modulator of the brain.
|