|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0005821,
umls-concept:C0011923,
umls-concept:C0087086,
umls-concept:C0303611,
umls-concept:C0597551,
umls-concept:C1167622,
umls-concept:C1514562,
umls-concept:C1527178,
umls-concept:C1705938,
umls-concept:C1879547,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1994-3-2
|
|
pubmed:abstractText |
Monoclonal antibodies which recognize fibrin or platelets have enabled imaging of vascular thrombi, however, early imaging has been difficult because of the slow blood disappearance of even small antibody fragments. It was theorized that it might be possible to synthesize peptides which possess the same thrombus affinity as monoclonal antibodies, but which would leave the blood pool much more rapidly.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0161-5505
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
282-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8295000-Amino Acid Sequence,
pubmed-meshheading:8295000-Animals,
pubmed-meshheading:8295000-Antibodies, Monoclonal,
pubmed-meshheading:8295000-Blood Platelets,
pubmed-meshheading:8295000-Dogs,
pubmed-meshheading:8295000-Molecular Sequence Data,
pubmed-meshheading:8295000-Organotechnetium Compounds,
pubmed-meshheading:8295000-Peptides,
pubmed-meshheading:8295000-Rabbits,
pubmed-meshheading:8295000-Sugar Acids,
pubmed-meshheading:8295000-Thrombosis
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Thrombus imaging with technetium-99m synthetic peptides based upon the binding domain of a monoclonal antibody to activated platelets.
|
|
pubmed:affiliation |
Nuclear Medicine Department, Temple University School of Medicine, Philadelphia, PA 19140.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
