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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-2-25
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pubmed:abstractText |
Several antigens of Mycobacterium tuberculosis have been identified by monoclonal antibodies and are being exploited in the development of improved vaccines and diagnostic reagents, but none has been linked to a specific function. Herein we report that the 38-kDa extracellular lipoprotein antigen, the most potent immunogen of the mycobacteria, is a phosphate-binding protein with features very similar to those of the well characterized periplasmic phosphate-binding protein of Escherichia coli which serves as an initial receptor for active transport. This is also the first report definitively linking a function of a binding protein anchored to a membrane and found in other than Gram-negative bacteria.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ag38 antigen, Mycobacterium...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphate-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
269
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pubmed:geneSymbol |
PBP
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1956-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8294447-Amino Acid Sequence,
pubmed-meshheading:8294447-Antibodies, Monoclonal,
pubmed-meshheading:8294447-Antigens, Bacterial,
pubmed-meshheading:8294447-Base Sequence,
pubmed-meshheading:8294447-Carrier Proteins,
pubmed-meshheading:8294447-Cloning, Molecular,
pubmed-meshheading:8294447-DNA Primers,
pubmed-meshheading:8294447-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8294447-Escherichia coli,
pubmed-meshheading:8294447-Genes, Bacterial,
pubmed-meshheading:8294447-Hydrogen Bonding,
pubmed-meshheading:8294447-Lipoproteins,
pubmed-meshheading:8294447-Membrane Proteins,
pubmed-meshheading:8294447-Molecular Sequence Data,
pubmed-meshheading:8294447-Molecular Weight,
pubmed-meshheading:8294447-Mycobacterium tuberculosis,
pubmed-meshheading:8294447-Phosphate-Binding Proteins,
pubmed-meshheading:8294447-Polymerase Chain Reaction,
pubmed-meshheading:8294447-Recombinant Proteins,
pubmed-meshheading:8294447-Sequence Homology, Amino Acid
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pubmed:year |
1994
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pubmed:articleTitle |
The immunodominant 38-kDa lipoprotein antigen of Mycobacterium tuberculosis is a phosphate-binding protein.
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pubmed:affiliation |
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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