Linked Life Data

829417

Source:http://linkedlifedata.com/resource/pubmed/id/829417

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
65
pubmed:dateCreated
1977-10-20
pubmed:abstractText
An hypothesis has been proposed by Holtzer and co-workers (1963, 1970, 1973) that the process of cell differentiation may be coupled in an obligatory manner with 'Quantal' cell cycle(s) which precede it. We have demonstrated that a 'wave' of DNA synthesis occurs in the neurectoderm of Xenopus laevis gastrula. This event of the cell cycle appears to be associated with the primary embryonic induction by the subjacent mesodermal tissue. The peak of DNA synthesis was observed in that area of the neurectoderm which was overlying the pre-chordal plate of mesoderm. Administration of 5-bromodeoxyuridine (BUdR) into the DNA of cells in a critical phase preceding overt differentiation, is known to perturb cytodifferentiation. In the present work sensitivity of X. laevis gastrula to BUdR (10(-3) M) has been investigated so as to assess the significance for neurogenesis of the wave of DNA synthesis in the neurectoderm.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0011-4529
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-30
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Correlation between the cell cycle in the neurectoderm and differentiation during the early development of Xenopus laevis. 1. BUdR sensitivity during gastrulation.
pubmed:publicationType
Journal Article