Linked Life Data

8293782

Source:http://linkedlifedata.com/resource/pubmed/id/8293782

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1994-3-3
pubmed:abstractText
Leucocyte accumulation and activation can lead to tissue injury subsequent to ischaemic insults and reperfusion. Post ischaemic leucocyte recruitment requires the coordinated function of at least four sets of adhesion receptors. Leucocyte rolling in microvessels is mediated by the selectin family of adhesion molecules and their carbohydrate ligands, while firm adhesion and transendothelial migration requires binding of integrin molecules on leucocytes to molecules of the immunoglobulin superfamily expressed on endothelial cells. Adhesion processes are exquisitely regulated at the transcriptional level, but also by conformational changes of proteins and enzymatic modifications of carbohydrate ligands. This article reviews the current knowledge on the function and regulation of adhesion molecules pertinent to leucocyte recruitment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0195-668X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14 Suppl I
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
68-73
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Molecular mechanisms of leucocyte rolling and adhesion to microvascular endothelium.
pubmed:affiliation
Department of Physiology, Freie Universität Berlin, Germany.
pubmed:publicationType
Journal Article, Review