| pubmed-article:8293295 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8293295 | lifeskim:mentions | umls-concept:C0597694 | lld:lifeskim |
| pubmed-article:8293295 | lifeskim:mentions | umls-concept:C0083727 | lld:lifeskim |
| pubmed-article:8293295 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:8293295 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8293295 | lifeskim:mentions | umls-concept:C1417847 | lld:lifeskim |
| pubmed-article:8293295 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8293295 | lifeskim:mentions | umls-concept:C0686907 | lld:lifeskim |
| pubmed-article:8293295 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8293295 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8293295 | pubmed:dateCreated | 1994-3-3 | lld:pubmed |
| pubmed-article:8293295 | pubmed:abstractText | RC3 (neurogranin) is a neuron-specific substrate of protein kinase C (PKC) that accumulates predominantly in dendritic spines of forebrain neurons and undergoes long-term potentiation (LTP)-associated increases in PKC-phosphorylation in hippocampal slices. Here the hypothesis that RC3 functions by modulating the IP3/DAG second messenger pathway after its phosphorylation by DAG-activated PKC was tested by heterologous expression in Xenopus oocytes. Acetylcholine-evoked inward chloride (Cl-) currents, dependent on both IP3 release and intracellular calcium (Ca2+), were 2- to 3-fold higher in RC3-injected oocytes than in uninjected control oocytes. RC3-oocytes did not exhibit enhanced currents when preincubated with the protein kinase inhibitor H-7 or when a glycine residue was substituted for serine, the PKC phosphorylation site of RC3. Activation of endogenous oocyte PKC by phorbol esters generated inward Cl- currents in RC3 oocytes but not in control oocytes. RC3-dependent Cl- currents were also elicited by phorbol ester in Ca(2+)-free media. We propose that PKC-phosphorylated RC3 is capable of enhancing the mobilization of intracellular Ca2+ in Xenopus oocytes and, by inference, may play a role in Ca2+ homeostasis in dendrites of forebrain neurons. | lld:pubmed |
| pubmed-article:8293295 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8293295 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8293295 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8293295 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8293295 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8293295 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8293295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8293295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8293295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8293295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8293295 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8293295 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8293295 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:8293295 | pubmed:author | pubmed-author:WatsonJ BJB | lld:pubmed |
| pubmed-article:8293295 | pubmed:author | pubmed-author:CohenR WRW | lld:pubmed |
| pubmed-article:8293295 | pubmed:author | pubmed-author:MarguliesJ... | lld:pubmed |
| pubmed-article:8293295 | pubmed:author | pubmed-author:CoulterP... | lld:pubmed |
| pubmed-article:8293295 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8293295 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:8293295 | pubmed:volume | 627 | lld:pubmed |
| pubmed-article:8293295 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8293295 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8293295 | pubmed:pagination | 147-52 | lld:pubmed |
| pubmed-article:8293295 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
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| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:meshHeading | pubmed-meshheading:8293295-... | lld:pubmed |
| pubmed-article:8293295 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8293295 | pubmed:articleTitle | Functional consequences of expression of the neuron-specific, protein kinase C substrate RC3 (neurogranin) in Xenopus oocytes. | lld:pubmed |
| pubmed-article:8293295 | pubmed:affiliation | Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine 90024. | lld:pubmed |
| pubmed-article:8293295 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8293295 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8293295 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8293295 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8293295 | lld:pubmed |
