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pubmed-article:8291253pubmed:abstractTextInterferon-gamma inhibits the growth of several viruses; however, the exact mechanism of this inhibition has not been clearly defined. In this report, we show that in a monocyte/macrophage cell line J774.G8 IFN-gamma inhibits the growth of vaccinia virus (VV) in a dose-dependent manner. This inhibition is due to a block in VV DNA synthesis and correlates with an increased generation of reactive nitrogen intermediates.lld:pubmed
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pubmed-article:8291253pubmed:articleTitleInterferon-gamma severely inhibits DNA synthesis of vaccinia virus in a macrophage cell line.lld:pubmed
pubmed-article:8291253pubmed:affiliationDepartment of Biochemistry, State University of New York, Brooklyn 11203.lld:pubmed
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