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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-2-24
|
| pubmed:abstractText |
Interferon-gamma inhibits the growth of several viruses; however, the exact mechanism of this inhibition has not been clearly defined. In this report, we show that in a monocyte/macrophage cell line J774.G8 IFN-gamma inhibits the growth of vaccinia virus (VV) in a dose-dependent manner. This inhibition is due to a block in VV DNA synthesis and correlates with an increased generation of reactive nitrogen intermediates.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0042-6822
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
198
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
731-5
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8291253-Animals,
pubmed-meshheading:8291253-Cell Line,
pubmed-meshheading:8291253-DNA, Viral,
pubmed-meshheading:8291253-DNA Replication,
pubmed-meshheading:8291253-Dose-Response Relationship, Drug,
pubmed-meshheading:8291253-Interferon-gamma,
pubmed-meshheading:8291253-Macrophages,
pubmed-meshheading:8291253-Mice,
pubmed-meshheading:8291253-Nitric Oxide,
pubmed-meshheading:8291253-Vaccinia virus
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Interferon-gamma severely inhibits DNA synthesis of vaccinia virus in a macrophage cell line.
|
| pubmed:affiliation |
Department of Biochemistry, State University of New York, Brooklyn 11203.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|