Linked Life Data

8291148

Source:http://linkedlifedata.com/resource/pubmed/id/8291148

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-2-18
pubmed:abstractText
Ionol, alpha-tocopherol and its analogues (tocoferenquinones with C6 and C1 in the side chain, tocopherol without the side chain and two tocopherols with shortened to C6 side chain both with saturated and with unsaturated bond at the end) were studied for their effect on the formation rate of malonaldehyde in the tissue and liver mitochondria of vitamin E-deficient rats in vitro. Preparations were used in two concentrations: 35 mg per 1 ml of the medium--in a dose suppressing processes or lipid peroxidation; and 5 mg per 1 ml of the medium--in a dose activating biosynthesis of ubiquinone in the animal tissues. Tocopherol effect on lipid peroxidation processes in the liver tissue and mitochondria is shown to be different and to depend on its concentration in the medium. Ionol is efficient only in high doses under the conditions in vitro. Tocopherol analogues (their side chain being shortened to six carbon atoms) display maximum activity when they inhibit lipid peroxidation both in the liver tissue and mitochondria in the both concentrations under study which supposes their high efficiency under the conditions in vivo.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0201-8470
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
94-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Effect of tocopherol, its analogs and the antioxidant ionol on lipid peroxidation in vitro].
pubmed:publicationType
Journal Article, In Vitro, English Abstract