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pubmed-article:8289194pubmed:abstractTextThis report describes the discovery of a new generation of tetracycline antibacterial agents, the "glycylcyclines". These agents are notable for their activity against a broad spectrum of tetracycline-susceptible and -resistant Gram-negative and Gram-positive aerobic and anaerobic bacteria possessing various classes of tetracycline-resistant determinants [tet B (efflux), tet M (ribosomal protection)]. The design and synthesis of a number of 7-substituted 9-substituted-amido 6-demethyl-6-deoxytetracyclines are described.lld:pubmed
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pubmed-article:8289194pubmed:articleTitleGlycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines.lld:pubmed
pubmed-article:8289194pubmed:affiliationAmerican Cyanamid Company, Medical Research Division, Pearl River, New York 10965.lld:pubmed
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