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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-2-22
|
| pubmed:abstractText |
This report describes the discovery of a new generation of tetracycline antibacterial agents, the "glycylcyclines". These agents are notable for their activity against a broad spectrum of tetracycline-susceptible and -resistant Gram-negative and Gram-positive aerobic and anaerobic bacteria possessing various classes of tetracycline-resistant determinants [tet B (efflux), tet M (ribosomal protection)]. The design and synthesis of a number of 7-substituted 9-substituted-amido 6-demethyl-6-deoxytetracyclines are described.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
7
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
184-8
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8289194-Anti-Bacterial Agents,
pubmed-meshheading:8289194-Enterococcus,
pubmed-meshheading:8289194-Escherichia coli,
pubmed-meshheading:8289194-Glycylglycine,
pubmed-meshheading:8289194-Molecular Structure,
pubmed-meshheading:8289194-Staphylococcus aureus,
pubmed-meshheading:8289194-Structure-Activity Relationship,
pubmed-meshheading:8289194-Tetracycline Resistance,
pubmed-meshheading:8289194-Tetracyclines
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines.
|
| pubmed:affiliation |
American Cyanamid Company, Medical Research Division, Pearl River, New York 10965.
|
| pubmed:publicationType |
Journal Article
|