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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-2-22
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pubmed:databankReference |
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pubmed:abstractText |
Human breakpoint cluster region (bcr) gene product is a member of a group of GTPase-activating proteins that act exclusively on members of the Ras-related Rho subfamily. A complementary DNA was isolated from Caenorhabditis elegans that encoded a polypeptide of 1438 amino acid residues, CeGAP, which contains a domain with sequence similarity to the COOH-terminal segment (GTPase-activating protein region) of Bcr and other known GTPase-activating proteins of the Rho subfamily. It also contains a "pleckstrin homology" motif, present in many signaling proteins including GTPase-activating proteins and nucleotide exchange factors. The Bcr-like domain of CeGAP exhibited activity not only on members of the C. elegans and human Rho subfamily but surprisingly also on C. elegans Ras protein (let-60), human Ras, and Rab3A. CeGAP is therefore the first GTPase-activating protein acting on Ras-related proteins across different subfamilies. Together with the presence of the pleckstrin homology motif, our finding suggests a central and integrative role for CeGAP in a signaling pathway common to Ras and related proteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
269
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pubmed:geneSymbol |
CeGAP,
rasGAP,
rhoGAP
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
820-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8288633-Amino Acid Sequence,
pubmed-meshheading:8288633-Animals,
pubmed-meshheading:8288633-Caenorhabditis elegans,
pubmed-meshheading:8288633-DNA, Complementary,
pubmed-meshheading:8288633-GTPase-Activating Proteins,
pubmed-meshheading:8288633-Genes, Helminth,
pubmed-meshheading:8288633-Introns,
pubmed-meshheading:8288633-Molecular Sequence Data,
pubmed-meshheading:8288633-Oncogene Proteins,
pubmed-meshheading:8288633-Protein-Tyrosine Kinases,
pubmed-meshheading:8288633-Proteins,
pubmed-meshheading:8288633-Proto-Oncogene Proteins,
pubmed-meshheading:8288633-Proto-Oncogene Proteins c-bcr,
pubmed-meshheading:8288633-Restriction Mapping,
pubmed-meshheading:8288633-Sequence Alignment,
pubmed-meshheading:8288633-Sequence Homology, Amino Acid,
pubmed-meshheading:8288633-Signal Transduction,
pubmed-meshheading:8288633-ras GTPase-Activating Proteins
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pubmed:year |
1994
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pubmed:articleTitle |
Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from Caenorhabditis elegans.
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pubmed:affiliation |
Institute of Molecular and Cell Biology, National University of Singapore.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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