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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1994-2-22
|
| pubmed:abstractText |
This report describes the effects of the porphyrin photosensitizers, Photofrin and benzoporphyrin derivative (BPD) on the immunohematopoietic system of normal and immunosuppressed DBA/2 mice in the absence of activating light. Photofrin (10 and 25 mg/kg) significantly increased in vitro colony formation by cells of the granulocyte-macrophage lineage in the spleen and bone marrow. Splenic hypercellularity, splenomegaly and elevated levels of blood leukocytes were observed in these mice 7 days following Photofrin injection. Evidence that Photofrin influenced the lymphohematopoietic compartment was suggested by a significant increase in blood lymphocytes and a population of spleen cells identified by a monoclonal antibody (LR-1) reactive with mouse splenic B lymphocytes. Proliferative responses of spleen cells from Photofrin-treated mice to sub-optimal concentrations of Con A were greater than that observed for controls. However, spleen cell responses to LPS were unaltered by Photofrin administration. In contrast, BPD (10 mg/kg) did not alter any of the immunohematopoietic parameters studied. When Photofrin was administered to mice treated with the myeloablative agent 5-FU there was a significant acceleration in the recovery of total blood leukocyte and spleen cell numbers, relative to the controls. These studies demonstrate that, in addition to its previously documented activities as a photosensitizer, Photofrin can exert stimulatory effects upon murine hematopoiesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Dihematoporphyrin Ether,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Porphyrins,
http://linkedlifedata.com/resource/pubmed/chemical/benzoporphyrin D
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0162-3109
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
203-12
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8288441-Animals,
pubmed-meshheading:8288441-Bone Marrow,
pubmed-meshheading:8288441-Bone Marrow Cells,
pubmed-meshheading:8288441-Cell Count,
pubmed-meshheading:8288441-Cells, Cultured,
pubmed-meshheading:8288441-Colony-Forming Units Assay,
pubmed-meshheading:8288441-Concanavalin A,
pubmed-meshheading:8288441-Dihematoporphyrin Ether,
pubmed-meshheading:8288441-Fluorouracil,
pubmed-meshheading:8288441-Hematopoiesis,
pubmed-meshheading:8288441-Immunosuppression,
pubmed-meshheading:8288441-Leukocyte Count,
pubmed-meshheading:8288441-Light,
pubmed-meshheading:8288441-Lipopolysaccharides,
pubmed-meshheading:8288441-Male,
pubmed-meshheading:8288441-Mice,
pubmed-meshheading:8288441-Mice, Inbred DBA,
pubmed-meshheading:8288441-Porphyrins,
pubmed-meshheading:8288441-Spleen
|
| pubmed:articleTitle |
Photofrin, but not benzoporphyrin derivative, stimulates hematopoiesis in the mouse.
|
| pubmed:affiliation |
Department of Microbiology, University of British Columbia, Vancouver, Canada.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|