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rdf:type |
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lifeskim:mentions |
umls-concept:C0004927,
umls-concept:C0055857,
umls-concept:C0079429,
umls-concept:C0162610,
umls-concept:C1514873,
umls-concept:C1527148,
umls-concept:C1546857,
umls-concept:C1547011,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1879746,
umls-concept:C2700640
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pubmed:issue |
1
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pubmed:dateCreated |
1994-2-23
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pubmed:databankReference |
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pubmed:abstractText |
Our genetic analysis indicates that the unc-101 gene of Caenorhabditis elegans is required for many aspects of development and behavior, including negative regulation of vulval differentiation. We have cloned unc-101 and found that it encodes a homolog of the mammalian medium chains of clathrin-associated protein complexes located at the trans-Golgi and the plasma membrane, AP47 and AP50, respectively. Therefore, clathrin-mediated events might contribute to the negative regulation of vulval differentiation. Comparison of sequences, including a full-length sequence of a C. elegans AP50 homolog, reveals that UNC-101 is most closely related to AP47. Mouse AP47 and nematode UNC-101 proteins are functionally equivalent as assayed in transgenic nematodes. We have sequenced the mutant alleles of unc-101 identified in various genetic screens and shown that all but one are deletions or nonsense mutations, suggesting that these alleles severely reduce unc-101 function.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Protein Complex 2,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Protein Complex mu Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Vesicular...,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Clathrin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/adaptor protein complex 2, mu 1...,
http://linkedlifedata.com/resource/pubmed/chemical/adaptor protein complex 2, mu 2...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:geneSymbol |
unc-101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
60-73
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8288128-Adaptor Protein Complex 2,
pubmed-meshheading:8288128-Adaptor Protein Complex mu Subunits,
pubmed-meshheading:8288128-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:8288128-Amino Acid Sequence,
pubmed-meshheading:8288128-Animals,
pubmed-meshheading:8288128-Base Sequence,
pubmed-meshheading:8288128-Behavior, Animal,
pubmed-meshheading:8288128-Caenorhabditis elegans,
pubmed-meshheading:8288128-Caenorhabditis elegans Proteins,
pubmed-meshheading:8288128-Clathrin,
pubmed-meshheading:8288128-Cloning, Molecular,
pubmed-meshheading:8288128-DNA,
pubmed-meshheading:8288128-Embryonic Induction,
pubmed-meshheading:8288128-Female,
pubmed-meshheading:8288128-Helminth Proteins,
pubmed-meshheading:8288128-Mice,
pubmed-meshheading:8288128-Molecular Sequence Data,
pubmed-meshheading:8288128-Mutation,
pubmed-meshheading:8288128-Nerve Tissue Proteins,
pubmed-meshheading:8288128-Phenotype,
pubmed-meshheading:8288128-Phosphoproteins,
pubmed-meshheading:8288128-Sequence Homology, Amino Acid,
pubmed-meshheading:8288128-Vulva
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pubmed:year |
1994
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pubmed:articleTitle |
unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.
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pubmed:affiliation |
Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91106.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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