Linked Life Data

8287925

Source:http://linkedlifedata.com/resource/pubmed/id/8287925

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-2-18
pubmed:abstractText
Pieces of isolated myenteric plexus, freshly dissected from the colon of young inbred Fischer rats, were implanted unilaterally into the corpus striatum of adult Fischer rats which had received a prior quinolinic acid lesion. Similar implants were made into the unlesioned striatum of a second group of Fischer rats. The survival of a subpopulation of grafted neurons, and the incidence of fiber outgrowth from these neurons into the host striatum, was examined after 3 and 6 weeks using a histochemical technique for the demonstration of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-diaphorase) activity. This enzyme is found both in some enteric neurons and a subpopulation of striatal neurons. Grafted enteric neurons expressing NADPH-diaphorase were easily distinguished in both the lesioned and unlesioned host striata at 3 and 6 weeks postimplantation. Fibers could be found extending from NADPH-diaphorase-containing enteric neurons into both the lesioned and unlesioned corpus striatum, although fewer graft-derived fibers were seen in the unlesioned striatum. This is the first demonstration that enteric neurons transplanted into the adult mammalian brain are capable of extending processes into the surrounding CNS tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Postnatal rat NADPH-diaphorase-containing myenteric neurons extend processes when transplanted into adult rat corpus striatum.
pubmed:affiliation
Department of Anatomy and Developmental Biology, University College London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't