| pubmed-article:8287917 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8287917 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8287917 | lifeskim:mentions | umls-concept:C0041632 | lld:lifeskim |
| pubmed-article:8287917 | lifeskim:mentions | umls-concept:C0059285 | lld:lifeskim |
| pubmed-article:8287917 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:8287917 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:8287917 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8287917 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8287917 | pubmed:dateCreated | 1994-2-24 | lld:pubmed |
| pubmed-article:8287917 | pubmed:abstractText | The mechanisms of endothelin-1-induced contractile response in the human umbilical artery were investigated in vitro. Autoradiography revealed 125I-endothelin-1 binding sites in the smooth muscle layer of the vessel wall. Endothelin-1 and sarafotoxin S6b induced concentration-dependent contractions while endothelin-3 was virtually without contractile effect. The endothelin ETA receptor antagonist BQ 123 did not affect the contraction to endothelin-1 but antagonized the contraction to sarafotoxin S6b. The contraction to endothelin-1 and sarafotoxin S6b was diminished by both verapamil and nicardipine. It can be concluded that endothelin-1 is a vasoconstrictor in the human umbilical artery, probably acting via more than one contraction-mediating receptor. The 125I-endothelin-1 binding sites demonstrated in the smooth muscle layer of the vessel may correspond to receptors mediating the contractile effect. The mechanisms of action seems to involve activation of Ca2+ channels. The present study does not give any evidence for interaction of endothelin-1 with other endothelium-derived vasoactive agents in this vessel. | lld:pubmed |
| pubmed-article:8287917 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8287917 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287917 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8287917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8287917 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8287917 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:8287917 | pubmed:author | pubmed-author:StjernquistMM | lld:pubmed |
| pubmed-article:8287917 | pubmed:author | pubmed-author:BodelssonGG | lld:pubmed |
| pubmed-article:8287917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8287917 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:8287917 | pubmed:volume | 249 | lld:pubmed |
| pubmed-article:8287917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8287917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8287917 | pubmed:pagination | 299-305 | lld:pubmed |
| pubmed-article:8287917 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8287917 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8287917 | pubmed:articleTitle | Characterization of endothelin receptors and localization of 125I-endothelin-1 binding sites in human umbilical artery. | lld:pubmed |
| pubmed-article:8287917 | pubmed:affiliation | Department of Obstetrics and Gynecology at Malmö, University of Lund, General Hospital, Sweden. | lld:pubmed |
| pubmed-article:8287917 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8287917 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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