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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-2-24
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pubmed:abstractText |
The mechanisms of endothelin-1-induced contractile response in the human umbilical artery were investigated in vitro. Autoradiography revealed 125I-endothelin-1 binding sites in the smooth muscle layer of the vessel wall. Endothelin-1 and sarafotoxin S6b induced concentration-dependent contractions while endothelin-3 was virtually without contractile effect. The endothelin ETA receptor antagonist BQ 123 did not affect the contraction to endothelin-1 but antagonized the contraction to sarafotoxin S6b. The contraction to endothelin-1 and sarafotoxin S6b was diminished by both verapamil and nicardipine. It can be concluded that endothelin-1 is a vasoconstrictor in the human umbilical artery, probably acting via more than one contraction-mediating receptor. The 125I-endothelin-1 binding sites demonstrated in the smooth muscle layer of the vessel may correspond to receptors mediating the contractile effect. The mechanisms of action seems to involve activation of Ca2+ channels. The present study does not give any evidence for interaction of endothelin-1 with other endothelium-derived vasoactive agents in this vessel.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelins,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Nicardipine,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Endothelin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Verapamil,
http://linkedlifedata.com/resource/pubmed/chemical/Viper Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/cyclo(Trp-Asp-Pro-Val-Leu),
http://linkedlifedata.com/resource/pubmed/chemical/omega-N-Methylarginine,
http://linkedlifedata.com/resource/pubmed/chemical/sarafotoxins s6
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
249
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-305
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8287917-Arginine,
pubmed-meshheading:8287917-Binding Sites,
pubmed-meshheading:8287917-Dose-Response Relationship, Drug,
pubmed-meshheading:8287917-Endothelins,
pubmed-meshheading:8287917-Endothelium, Vascular,
pubmed-meshheading:8287917-Humans,
pubmed-meshheading:8287917-Iodine Radioisotopes,
pubmed-meshheading:8287917-Muscle, Smooth, Vascular,
pubmed-meshheading:8287917-Muscle Contraction,
pubmed-meshheading:8287917-Nicardipine,
pubmed-meshheading:8287917-Peptides, Cyclic,
pubmed-meshheading:8287917-Receptors, Endothelin,
pubmed-meshheading:8287917-Umbilical Arteries,
pubmed-meshheading:8287917-Vasoconstriction,
pubmed-meshheading:8287917-Vasoconstrictor Agents,
pubmed-meshheading:8287917-Verapamil,
pubmed-meshheading:8287917-Viper Venoms,
pubmed-meshheading:8287917-omega-N-Methylarginine
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pubmed:year |
1993
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pubmed:articleTitle |
Characterization of endothelin receptors and localization of 125I-endothelin-1 binding sites in human umbilical artery.
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pubmed:affiliation |
Department of Obstetrics and Gynecology at Malmö, University of Lund, General Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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