| pubmed-article:8287370 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8287370 | lifeskim:mentions | umls-concept:C1704939 | lld:lifeskim |
| pubmed-article:8287370 | lifeskim:mentions | umls-concept:C0010531 | lld:lifeskim |
| pubmed-article:8287370 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8287370 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8287370 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:8287370 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8287370 | lifeskim:mentions | umls-concept:C0120551 | lld:lifeskim |
| pubmed-article:8287370 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:8287370 | pubmed:dateCreated | 1994-2-24 | lld:pubmed |
| pubmed-article:8287370 | pubmed:abstractText | N-[2-(p-bromocinnamylmethylamino) ethyl]-5-isoquinolinesulfonamide (H-87), a newly synthesized inhibitor of protein kinase A, significantly decreased the drug resistance of multidrug resistant human U937/M cells, mouse FM3A/M and P388/M cells. Northern blot analysis showed MDR1 gene expression was decreased in H-87-treated P388 M cells. H-87 inhibited the activity of MDR1 (multidrug resistance-1) promoter in a dose-dependent manner in transient expression assay. In contrast, the expression of c-raf-1 gene significantly enhanced the activity of MDR1 promoter. We therefore examined the effect of H-87 on MDR1 gene expression in c-raf-1 transfected CV-1 cells (CV-1/raf). A significant decrease in the level of MDR1 mRNA was observed after H-87 treatment of the CV-1/raf cells. These results suggest that inhibition of MDR1 gene expression by H-87 is associated with circumvention of drug resistance in MDR cells. | lld:pubmed |
| pubmed-article:8287370 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8287370 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287370 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8287370 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8287370 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:8287370 | pubmed:author | pubmed-author:HidakaHH | lld:pubmed |
| pubmed-article:8287370 | pubmed:author | pubmed-author:MOER ERE | lld:pubmed |
| pubmed-article:8287370 | pubmed:author | pubmed-author:ChungB SBS | lld:pubmed |
| pubmed-article:8287370 | pubmed:author | pubmed-author:ParkJ IJI | lld:pubmed |
| pubmed-article:8287370 | pubmed:author | pubmed-author:KangC DCD | lld:pubmed |
| pubmed-article:8287370 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8287370 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8287370 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:8287370 | pubmed:geneSymbol | c-raf-1 | lld:pubmed |
| pubmed-article:8287370 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8287370 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8287370 | pubmed:pagination | 37-41 | lld:pubmed |
| pubmed-article:8287370 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8287370 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8287370 | pubmed:articleTitle | Inhibition of MDR1 gene expression by H-87, a selective inhibitor of cAMP-dependent protein kinase. | lld:pubmed |
| pubmed-article:8287370 | pubmed:affiliation | Department of Biochemistry, College of Medicine, Pusan National University, Korea. | lld:pubmed |
| pubmed-article:8287370 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8287370 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8287370 | lld:pubmed |
