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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-2-24
|
| pubmed:abstractText |
A new, radioiodinated, NK1 selective radiotracer ([125I]L-703,606) was prepared. L-703,606 is an iodinated analog of the NK1 antagonist CP-96,345 in which the methoxy group has been replaced by an iodine substituent. [125I]L-703,606 was made from the corresponding trimethylsilyl compound by treatment with no carrier added Na 125I and an Iodobead in TFA. The tracer was prepared at a specific activity of approx. 1100 Ci/mmol and preliminary binding studies demonstrated that [125I]L-703,606 binds selectively to NK1 receptors with a kd = 0.3 nM. These results suggest that this radioligand will be useful for the biochemical and pharmacological characterization of the human NK1 receptor and, if labeled with I-123, may be useful for non-invasive NK1 receptor imaging via SPECT.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0969-8043
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
97-103
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1994
|
| pubmed:articleTitle |
Radioiodinated L-703,606: a potent, selective antagonist to the human NK1 receptor.
|
| pubmed:affiliation |
Department of Radiopharmacology, Merck Research Laboratories, West Point, PA 19486.
|
| pubmed:publicationType |
Journal Article
|