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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-2-18
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pubmed:abstractText |
E-cadherin (E-CD) is a calcium-dependent cell-cell adhesion molecule which is expressed in almost all epithelial tissues. E-CD expression is involved in epidermal morphogenesis and is reduced during tumour progression of mouse epidermal carcinogenesis. It has been suggested that E-CD could play a role as an invasion-suppressor molecule. In the present work we have studied the E-CD expression in 31 patients with basal cell carcinoma (BCC) using an immunohistochemical technique with a monoclonal antibody (HECD-1) specific for human E-CD. E-CD expression was preserved in all specimens of superficial and nodular BCC, and was reduced in 10 of 15 infiltrative BCCs. A heterogeneous distribution of cells with different immunostaining intensity was more frequently observed in specimens of infiltrative BCC. These results suggest that E-CD might be related to the growth pattern and the local aggressive behaviour of BCC, and support the idea that E-CD might play a role as an invasion-suppressor molecule in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1316085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1333788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1373144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1384639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1390146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1394201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1419753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1469507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-14731794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-14731985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1514246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1516067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1581909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1615930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1639852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1649199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1713020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1851053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1869642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1918152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1931086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1933895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1952969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-1999506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2006419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2007622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2009537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2010235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2033490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2070412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2070502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2502522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2661563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2702654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2774055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-2806126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-3734235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-6736323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-7682766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-7682767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-8383197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-8425900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-8435813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-8453643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-8453644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8286199-8494723
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8286199-Adult,
pubmed-meshheading:8286199-Aged,
pubmed-meshheading:8286199-Aged, 80 and over,
pubmed-meshheading:8286199-Antibodies, Monoclonal,
pubmed-meshheading:8286199-Cadherins,
pubmed-meshheading:8286199-Carcinoma, Basal Cell,
pubmed-meshheading:8286199-Cell Division,
pubmed-meshheading:8286199-Female,
pubmed-meshheading:8286199-Humans,
pubmed-meshheading:8286199-Immunohistochemistry,
pubmed-meshheading:8286199-Male,
pubmed-meshheading:8286199-Middle Aged,
pubmed-meshheading:8286199-Neoplasm Invasiveness,
pubmed-meshheading:8286199-Skin,
pubmed-meshheading:8286199-Skin Neoplasms
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pubmed:year |
1994
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pubmed:articleTitle |
E-cadherin expression in basal cell carcinoma.
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pubmed:affiliation |
Servicio de Dermatologia, Hospital La Paz, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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