| pubmed-article:8285253 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8285253 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8285253 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8285253 | lifeskim:mentions | umls-concept:C0079281 | lld:lifeskim |
| pubmed-article:8285253 | lifeskim:mentions | umls-concept:C0025465 | lld:lifeskim |
| pubmed-article:8285253 | lifeskim:mentions | umls-concept:C1524003 | lld:lifeskim |
| pubmed-article:8285253 | pubmed:issue | 6 Pt 2 | lld:pubmed |
| pubmed-article:8285253 | pubmed:dateCreated | 1994-2-14 | lld:pubmed |
| pubmed-article:8285253 | pubmed:abstractText | The present study was designed to determine whether endothelin (ET) induces endothelium-dependent hyperpolarization in the isolated rat mesenteric artery and, if so, to identify the receptor subtype involved. Main superior mesenteric arteries of Wistar-Kyoto and spontaneously hypertensive rats were used for the measurement of electrical responses of smooth muscle cells, using glass microelectrode. In tissues with endothelium of both strains, ET-1 (10(-8) M) caused an initial transient hyperpolarization followed by a sustained depolarization. In tissues without endothelium, only depolarization was observed. ET-3 (10(-8) M) produced transient hyperpolarizations only in preparations with endothelium. There was no significant difference in maximal amplitude of hyperpolarization between the two strains. BQ-123 (selective ETA-receptor antagonist) blocked the depolarization to ET-1 but did not inhibit hyperpolarizing responses to either isopeptide. IRL-1620 (specific ETB-receptor agonist) produced transient membrane hyperpolarizations in tissues with endothelium. The hyperpolarizations induced by ET were not affected by NG-nitro-L-arginine. These data suggest that both ET-1 and ET-3 can cause endothelium-dependent hyperpolarization in the rat mesenteric artery and that the endothelial receptor involved may belong to ETB subtype. | lld:pubmed |
| pubmed-article:8285253 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8285253 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8285253 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8285253 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8285253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8285253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8285253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8285253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8285253 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8285253 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8285253 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8285253 | pubmed:author | pubmed-author:VanhoutteP... | lld:pubmed |
| pubmed-article:8285253 | pubmed:author | pubmed-author:NakashimaMM | lld:pubmed |
| pubmed-article:8285253 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8285253 | pubmed:volume | 265 | lld:pubmed |
| pubmed-article:8285253 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8285253 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8285253 | pubmed:pagination | H2137-41 | lld:pubmed |
| pubmed-article:8285253 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:meshHeading | pubmed-meshheading:8285253-... | lld:pubmed |
| pubmed-article:8285253 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8285253 | pubmed:articleTitle | Endothelin-1 and -3 cause endothelium-dependent hyperpolarization in the rat mesenteric artery. | lld:pubmed |
| pubmed-article:8285253 | pubmed:affiliation | Center for Experimental Therapeutics, Baylor College of Medicine, Houston, Texas 77030. | lld:pubmed |
| pubmed-article:8285253 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8285253 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8285253 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8285253 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8285253 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8285253 | lld:pubmed |
