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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1994-2-14
|
| pubmed:abstractText |
Further studies on the active constituents in the bulbs of Allium macrostemon Bunge led to the isolation and structural determination of two new furostanol saponin macrostemonoside E and F. On the basis of chemical evidences and spectral analysis (UV, IR, 1H-NMR, 13C-NMR and FAB-MS), the structure of macrostemonoside E(I) was elucidated as (25R)-26-O-beta-D-glucopyranosyl-5 alpha-furost-20(22)-ene-3 beta,26-diol-3-O- beta-D-glucopyranosyl (1-->2) [beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranosyl (1-->4)-beta-D-galactopyranoside; macrostemonoside F(II) was established to be (25R)-26-O-beta-D-glucopyranosyl-5 beta-furost-20(22)-ene-3 beta,26-diol-3-O- beta-D-glucopyranosyl (1-->2)-beta-D-galactoside. Preliminary pharmacological tests showed that both macrostemonoside E and F could strongly inhibit ADP-induced human platelet aggregation in vitro. The IC50 of the former was 0.417 mM and that of the latter was 0.020 mM.
|
| pubmed:language |
chi
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0513-4870
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
526-31
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1993
|
| pubmed:articleTitle |
[Studies on two new furostanol glycosides from Allium macrostemon Bunge].
|
| pubmed:affiliation |
Department of Phytochemistry, Shenyang College of Pharmacy.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|