Linked Life Data

8284328

Source:http://linkedlifedata.com/resource/pubmed/id/8284328

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-2-14
pubmed:abstractText
The crystal structure of 2,3-dihydroxy-etiochlorin I has been determined to obtain information on its aggregation behavior. Cis-dihydroxychlorins serve as model compounds for green heme d and show promising photonecrotic activity in photodynamic therapy. The compound shows strong aggregation in the solid state facilitated by intramolecular hydrogen bonding between one hydroxy group and pyrrole nitrogens of neighboring molecules. This novel type of aggregation leads to chain-type aggregates in the crystal. The title compound 4 crystallized in the monoclinic space group Ia (Z = 4) with unit cell dimensions a = 9.902(4) A, b = 26.430(9) A, c = 10.823(5), beta = 104.47(3) A, V = 2743(2) A3. The structure was refined to an R-value of 0.097 on the basis of 1150 reflections with F > 4.0 sigma (F) (130 K).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0031-8655
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
748-52
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Aggregation of 2,3-dihydroxy-etiochlorin I. An amphiphilic model compound for photodynamic therapy and green heme d.
pubmed:affiliation
Department of Chemistry, University of California, Davis 95616.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.