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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1994-2-17
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pubmed:abstractText |
We compared in 12- to 15-month-old American Indian infants the safety and immunogenicity of two licensed Haemophilus influenzae type b (Hib) conjugate vaccines, PRP-OMP (PedvaxHib) and HbOC (HibTITER), administered as booster vaccinations. All infants previously received PRP-OMP for their primary Hib vaccinations at 2 and 4 months of age. The geometric mean Hib antibody concentrations (microgram/ml) measured by radioactive antigen-binding assay for those receiving PRP-OMP (n = 17) or HbOC (n = 18) were 0.593 and 0.449, respectively, before boosting (P not significant) and 7.46 and 29.5 micrograms/ml, respectively, after boosting (P < 0.05). PRP-OMP recipients also had lower geometric mean IgG anti-Hib antibody concentrations than HbOC recipients (7.21 vs 28 micrograms/ml, P = 0.003) and lower bactericidal titers (3.18 vs. 15.4, not significant). We conclude that HbOC vaccine produced a significantly greater booster response than PRP-OMP vaccine when given at 12 to 15 months of age to children primed with two doses of PRP-OMP vaccine at 2 and 4 months of age.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Outer Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Haemophilus Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Haemophilus influenzae-type b...,
http://linkedlifedata.com/resource/pubmed/chemical/HibTITER protein, Haemophilus...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Conjugate,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0891-3668
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
812-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8284116-Antibodies, Bacterial,
pubmed-meshheading:8284116-Arizona,
pubmed-meshheading:8284116-Bacterial Outer Membrane Proteins,
pubmed-meshheading:8284116-Bacterial Proteins,
pubmed-meshheading:8284116-Haemophilus Infections,
pubmed-meshheading:8284116-Haemophilus Vaccines,
pubmed-meshheading:8284116-Haemophilus influenzae,
pubmed-meshheading:8284116-Humans,
pubmed-meshheading:8284116-Immunization, Secondary,
pubmed-meshheading:8284116-Immunoglobulin A,
pubmed-meshheading:8284116-Immunoglobulin G,
pubmed-meshheading:8284116-Immunoglobulin M,
pubmed-meshheading:8284116-Indians, North American,
pubmed-meshheading:8284116-Infant,
pubmed-meshheading:8284116-Polysaccharides, Bacterial,
pubmed-meshheading:8284116-Vaccines, Conjugate,
pubmed-meshheading:8284116-Vaccines, Synthetic
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pubmed:year |
1993
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pubmed:articleTitle |
Antibody response of Navajo children primed with PRP-OMP vaccine to booster doses of PRP-OMP vs. HbOC vaccine.
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pubmed:affiliation |
Johns Hopkins Project, Whiteriver, AZ.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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