Linked Life Data

8284044

Source:http://linkedlifedata.com/resource/pubmed/id/8284044

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-2-14
pubmed:abstractText
We investigated the temporal profile of heat shock protein 70 induction in the rat hippocampus using immunohistochemistry to clarify the mechanism of ischemic tolerance following preconditioning with sublethal ischemia. Although a 6-min period of forebrain ischemia produced severe neuronal damage to the hippocampal CA1 subfield, preconditioning with 3 min of ischemia followed by three days of reperfusion protected against the CA1 neuronal damage after 6 min of ischemia. Immunohistochemical staining against heat shock protein 70 showed that the protein is induced in CA1 pyramidal cells one, three and seven days after 3 min of ischemia, the immunostaining being most intense after three days. Heat shock protein synthesis was observed in CA1, CA3 and dentate hilar neurons one and three days after 6 min of ischemia, both with and without preconditioning. In addition, the heat shock protein was stained in the CA1 2 h and seven days after 6 min of ischemia with preconditioning, but the intensity of staining was relatively weak at these time points. The results suggest that stress response induced by sublethal ischemia protects against ischemic neuronal damage, and that the induced stress response, including heat shock protein 70 synthesis during and immediately after the second ischemic episode, is correlated with the protection because late induction of the heat shock protein did not prevent neuronal death.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
921-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Temporal profile of heat shock protein 70 synthesis in ischemic tolerance induced by preconditioning ischemia in rat hippocampus.
pubmed:affiliation
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
pubmed:publicationType
Journal Article