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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8104-5
|
| pubmed:dateCreated |
1979-2-23
|
| pubmed:abstractText |
Serum angiotensin-converting enzyme (SACE) activity was significantly higher in 90 patients with sarcoidosis (55 +/- [S.D.] 23 nmol min-1 ml-1) than in 80 healthy controls (34 +/- 9 nmol min-1 ml-1). Steroid therapy modified SACE activity; 60 sarcoidosis patients who were not being treated with steroids had significantly higher enzyme activities (58 +/- 24 nmol min-1 ml-1) than 30 steroid-treated sarcoidosis patients (40 +/- 19 nmol min-1 ml-1). In 50% of the non-steroid treated sarcoidosis patients SACE activity was more than 2 S.D. above the mean value for the controls. SACE activity was measured in 22 tuberculous patients (38 +/- 14 nmol min-1 ml-1), 20 leprosy patients (34 +/- 9 nmol min-1 ml-1), 31 with primary biliary cirrhosis (44 +/- 20 nmol min-1 ml-1), 26 with inflammatory bowel disease (31 +/- 9 nmol min-1 ml-1), 8 with hepatic granulomatous disease, 5 with Hodgkin's disease, and 2 with schistosomiasis. The combined false-positive rate for these non-sarcoidosis patients was 10%. Serial SACE assays provide useful information on the course of sarcoidosis and response to steroid treatment.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1331-4
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| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:82838-Acute Disease,
pubmed-meshheading:82838-Adolescent,
pubmed-meshheading:82838-Adult,
pubmed-meshheading:82838-Aged,
pubmed-meshheading:82838-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:82838-Chronic Disease,
pubmed-meshheading:82838-Enteritis,
pubmed-meshheading:82838-Enzyme Inhibitors,
pubmed-meshheading:82838-Female,
pubmed-meshheading:82838-Granuloma,
pubmed-meshheading:82838-Hodgkin Disease,
pubmed-meshheading:82838-Humans,
pubmed-meshheading:82838-Leprosy,
pubmed-meshheading:82838-Liver Cirrhosis, Biliary,
pubmed-meshheading:82838-Liver Diseases,
pubmed-meshheading:82838-Male,
pubmed-meshheading:82838-Middle Aged,
pubmed-meshheading:82838-Peptidyl-Dipeptidase A,
pubmed-meshheading:82838-Prednisolone,
pubmed-meshheading:82838-Sarcoidosis,
pubmed-meshheading:82838-Schistosomiasis,
pubmed-meshheading:82838-Tuberculosis, Pulmonary
|
| pubmed:articleTitle |
Serum angiotensin-converting enzyme (SACE) in sarcoidosis and other granulomatous disorders.
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| pubmed:publicationType |
Journal Article
|