Linked Life Data

828374

Source:http://linkedlifedata.com/resource/pubmed/id/828374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1977-4-25
pubmed:abstractText
On the potassium contracture of isolated coronary arteries of cattle, the relaxation effected by calcium depletion can be blocked by lanthanum ions. The contracture persisting in calcium-free solution (arrested potassium contracture) is used to differentiate the sites of attack of spasmolytics. Verapamil and prenylamine are ineffective in this contracture model. By contrast, nitroprusside sodium and nitroglycerol as before act spasmolytically. Thus, both groups of drugs act through basically different sites. The findings are consistent with the hypothesis that the spasmolytic action of verapamil and prenylamine is based on a blockade of calcium influx. For nitroprusside sodium and nitroglycerol such a mechanism on the arrested potassium contracture has to be ruled out.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5318
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1347-58
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
[Experments on the mechanism of action of vascular spasmolytic agents. I. Effect nitroprusside sodium, nitroglycerine, prenylamine and verapamil on the arrested potassium contracture of isolated coronary arteries].
pubmed:publicationType
Journal Article, English Abstract