Linked Life Data

8283226

Source:http://linkedlifedata.com/resource/pubmed/id/8283226

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-2-15
pubmed:abstractText
1. Chorda tympani (CT) neural responses to NaCl were recorded while the potential across the apical membrane of taste cells was perturbed by voltage clamp in rats fed a Na(+)-restricted diet pre- and postnatally (Na(+)-restricted rats) and in controls. 2. Control rats gave CT responses that were enhanced at negative voltage clamp and suppressed at positive voltage clamp. In contrast, CT responses from Na(+)-restricted rats were virtually voltage insensitive. 3. Analysis of the voltage-sensitivity of the CT response shows that Na(+)-restricted rats have < 10% of the density of functional apical Na+ channels normally present in control rats demonstrating that early dietary Na(+)-restriction prevents the functional expression of these key elements in salt taste transduction. Furthermore, the data demonstrate the value of this technique in assessing involvement of distinct cellular domains in taste transduction.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3077
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1713-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Dietary Na(+)-restriction prevents development of functional Na+ channels in taste cell apical membranes: proof by in vivo membrane voltage perturbation.
pubmed:affiliation
Department of Physiology, Virginia Commonwealth University, Richmond 23298.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.