Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1994-2-17
|
pubmed:abstractText |
The multiple sclerosis (MS) case-control ratio by state originating from the U.S. veteran series from World War II (Kurtzke Neurology 1979; 29: 1228-1235) was geographically compared with 46 sociogeographic variables from the period 1935-1958. Latitude was, by far, the variable most closely associated with MS in univariate testing. Multivariate analysis by factor analysis revealed that the MS rate was associated with 2 independent settings ("factors"). The first one was defined mainly socioeconomically and was characterized by indicators of higher affluence; better nutrition with a higher meat consumption in particular, and a higher sanitary level were the prominent features. The second MS-related bundle comprised characteristics of a colder climate along with further dietary variables (i.e. a diet low in fish and high in dairy products). The findings suggest a possible interaction of both socioeconomic and geoclimatic features in the etiology of MS; sanitation, diet and climate being of particular interest.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0895-4356
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
43-8
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:8283194-Adult,
pubmed-meshheading:8283194-Case-Control Studies,
pubmed-meshheading:8283194-Climate,
pubmed-meshheading:8283194-Diet,
pubmed-meshheading:8283194-Factor Analysis, Statistical,
pubmed-meshheading:8283194-Female,
pubmed-meshheading:8283194-Geography,
pubmed-meshheading:8283194-Humans,
pubmed-meshheading:8283194-Male,
pubmed-meshheading:8283194-Multiple Sclerosis,
pubmed-meshheading:8283194-Multivariate Analysis,
pubmed-meshheading:8283194-Nutritional Physiological Phenomena,
pubmed-meshheading:8283194-Risk Factors,
pubmed-meshheading:8283194-Sanitation,
pubmed-meshheading:8283194-Socioeconomic Factors,
pubmed-meshheading:8283194-United States
|
pubmed:year |
1994
|
pubmed:articleTitle |
The risk of multiple sclerosis in the U.S.A. in relation to sociogeographic features: a factor-analytic study.
|
pubmed:affiliation |
Department of Neurology, Academic Teaching Hospital, Darmstadt, Germany.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|