Linked Life Data

8282970

Source:http://linkedlifedata.com/resource/pubmed/id/8282970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-2-17
pubmed:abstractText
Most gerontological research is conducted using inbred strains of animals in an attempt to maximize phenotypic uniformity within experiments and thus increase the experimenter's statistical power to detect treatment effects. However, for a wide range of phenotypic traits, F1 hybrids between inbred strains are considerably less variable than the parental inbred strains themselves. Therefore, the use of F1 hybrids is preferable for many research applications. In this article, we discuss the sources of phenotypic variability and explain why F1 hybrids are often less variable than inbred strains; we review the empirical literature illustrating the large range of species and traits for which this is true; and finally we suggest how this finding suggests that F1 hybrids may often be superior animal models for studying the aging process and how to manipulate it.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1422
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
B1-11
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Selecting animal models of human aging: inbred strains often exhibit less biological uniformity than F1 hybrids.
pubmed:affiliation
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review