Linked Life Data

8282029

Source:http://linkedlifedata.com/resource/pubmed/id/8282029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-2-15
pubmed:abstractText
Catabolism of hyaluronan was studied by injecting hyaluronan (M(r) 200,000) labelled with [125I]-tyramine cellobiose, ([125I]-TC), into the anterior chamber of the rabbit eye. After endocytosis [125I]-TC accumulates in cells, allowing localization of the site of catabolism. When 0.1 ml of the aqueous humour was replaced with an equal volume containing polymer in tracer quantities, 24% was recovered from the eye at 2 hr and 6.5% at 6 hr after injection. With replacement of 0.2 ml of aqueous humour 38% and 19%, respectively, were found within the eye at the same time points. Most of the radioactivity was found in the liver. If the tracer was mixed with Healon the removal from the anterior chamber was delayed. Chromatography on Sephacryl S-300 showed that there was no significant degradation of the labelled polymer in the aqueous humour nor in the remaining parts of the enucleated eye, while most of the tracer extracted from the liver was of low molecular weight. Thus the labelled hyaluronan was being washed out of the eye and subsequently taken up and catabolized by the liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Hyaluronan injected in the anterior chamber of the eye is catabolized in the liver.
pubmed:affiliation
Department of Ophthalmology, University of Uppsala, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't