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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1994-2-14
|
| pubmed:abstractText |
Cultured astrocytes contain immunologically specific aromatic L-amino acid decarboxylase (AADC) protein and express the AADC gene. Following incubation with L-Dopa, glial cultures synthesize and metabolize dopamine. The addition of pyridoxal 5-phosphate did not change the rate of dopamine synthesis. The formation of dopamine was blocked by NSD-1015. These experiments show that mouse cultured astrocytes are capable to convert L-Dopa into dopamine in a dose-dependent fashion.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
626
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
306-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8281440-Animals,
pubmed-meshheading:8281440-Aromatic-L-Amino-Acid Decarboxylases,
pubmed-meshheading:8281440-Astrocytes,
pubmed-meshheading:8281440-Cells, Cultured,
pubmed-meshheading:8281440-Decarboxylation,
pubmed-meshheading:8281440-Gene Expression,
pubmed-meshheading:8281440-Levodopa,
pubmed-meshheading:8281440-Mice
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Decarboxylation of L-dopa by cultured mouse astrocytes.
|
| pubmed:affiliation |
Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|