rdf:type |
|
lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0024779,
umls-concept:C0036576,
umls-concept:C0040649,
umls-concept:C0086418,
umls-concept:C0100700,
umls-concept:C0205147,
umls-concept:C0439851,
umls-concept:C0441513,
umls-concept:C1333652,
umls-concept:C1527177,
umls-concept:C1552596,
umls-concept:C1708726,
umls-concept:C1947931
|
pubmed:issue |
11
|
pubmed:dateCreated |
1994-2-17
|
pubmed:databankReference |
|
pubmed:abstractText |
A transcription map covering a 300 kb region around the G6PD gene in the human Xq28 region was constructed by the direct cDNA selection method and the analysis of the resulting region-specific enriched cDNA sublibrary. Seven new genes and two loci of endogenous retrovirus HERV-K were identified. The distribution of the genes across the region is strongly non-uniform and follows the non-uniform distribution of GpG islands in the area. While one of the novel genes was found to be highly homologous to bovine smg p25A GDP-dissociation inhibitor, the remaining genes did not detect any homology to known genes. The analysis of region-specific cDNA sublibraries represents a simple, rapid and efficient tool for the generation of a regional transcription map.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0964-6906
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1865-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8281148-Animals,
pubmed-meshheading:8281148-Cattle,
pubmed-meshheading:8281148-Chromosome Mapping,
pubmed-meshheading:8281148-DNA, Complementary,
pubmed-meshheading:8281148-Dinucleoside Phosphates,
pubmed-meshheading:8281148-GTP-Binding Proteins,
pubmed-meshheading:8281148-Gene Library,
pubmed-meshheading:8281148-Glucosephosphate Dehydrogenase,
pubmed-meshheading:8281148-Humans,
pubmed-meshheading:8281148-Molecular Sequence Data,
pubmed-meshheading:8281148-Organ Specificity,
pubmed-meshheading:8281148-Restriction Mapping,
pubmed-meshheading:8281148-Retroviridae,
pubmed-meshheading:8281148-Sequence Homology, Nucleic Acid,
pubmed-meshheading:8281148-Transcription, Genetic,
pubmed-meshheading:8281148-X Chromosome,
pubmed-meshheading:8281148-rab3 GTP-Binding Proteins
|
pubmed:year |
1993
|
pubmed:articleTitle |
Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection.
|
pubmed:affiliation |
Deutsches Krebsforschungszentrum, Heidelberg, Germany.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|