| pubmed-article:8280609 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C1709854 | lld:lifeskim |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C0025166 | lld:lifeskim |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C0006463 | lld:lifeskim |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C0010583 | lld:lifeskim |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C1947989 | lld:lifeskim |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C1521827 | lld:lifeskim |
| pubmed-article:8280609 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:8280609 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8280609 | pubmed:dateCreated | 1994-2-15 | lld:pubmed |
| pubmed-article:8280609 | pubmed:abstractText | Increased megakaryocyte colony stimulating activity (MK-CSA) has been reported after total body irradiation (TBI) for bone marrow transplant (BMT). We studied the effect of a busulfan (Bu) and cyclophosphamide (Cy) marrow transplant conditioning regimen, without radiation, on MK-CSA production. Initial screening of MK-CSA was done on previously collected and banked sera from 14 BMT patients. MK-CSA was expressed as the ability to stimulate growth of megakaryocyte progenitors (CFU-MK) in standard plasma clot cultures. In the initial samples, MK-CSA peaked at day 7. This preliminary data led to a prospective study of MK-CSA and clinical parameters in seven allogeneic recipients. MK-CSA activity increased from day -7 pre-transplant (2.9 +/- 1.7 CFU-MK/10(5) NATD, mean +/- SD) to day 0 (10.3 +/- 4.7 CFU-MK) and peaked by day 9 post-transplant (20.6 +/- 6.4 CFU-MK). MK-CSA activity decreased in all seven patients by day 21 at which time five of seven patients studied had recovery of platelet counts to greater than 100 x 10(9)/l. MK-CSA activity rose rapidly in both groups of sera after the initiation of this non-irradiation, BMT preparative regimen. High MK-CSA levels, early after transplant, may contribute to the rapid platelet recovery in some patients. | lld:pubmed |
| pubmed-article:8280609 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8280609 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280609 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8280609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8280609 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8280609 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8280609 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:8280609 | pubmed:author | pubmed-author:KapoorNN | lld:pubmed |
| pubmed-article:8280609 | pubmed:author | pubmed-author:OlsonT ATA | lld:pubmed |
| pubmed-article:8280609 | pubmed:author | pubmed-author:TutschkaPP | lld:pubmed |
| pubmed-article:8280609 | pubmed:author | pubmed-author:WingCC | lld:pubmed |
| pubmed-article:8280609 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8280609 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:8280609 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8280609 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8280609 | pubmed:pagination | 365-70 | lld:pubmed |
| pubmed-article:8280609 | pubmed:dateRevised | 2011-10-26 | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
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| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
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| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:meshHeading | pubmed-meshheading:8280609-... | lld:pubmed |
| pubmed-article:8280609 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8280609 | pubmed:articleTitle | Megakaryocyte colony stimulating activity in allogenic bone marrow recipients prepared with busulfan and cyclophosphamide. | lld:pubmed |
| pubmed-article:8280609 | pubmed:affiliation | Department of Pediatrics, Columbus Children's Hospital, Ohio State University. | lld:pubmed |
| pubmed-article:8280609 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8280609 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
