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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-2-15
|
| pubmed:abstractText |
Increased megakaryocyte colony stimulating activity (MK-CSA) has been reported after total body irradiation (TBI) for bone marrow transplant (BMT). We studied the effect of a busulfan (Bu) and cyclophosphamide (Cy) marrow transplant conditioning regimen, without radiation, on MK-CSA production. Initial screening of MK-CSA was done on previously collected and banked sera from 14 BMT patients. MK-CSA was expressed as the ability to stimulate growth of megakaryocyte progenitors (CFU-MK) in standard plasma clot cultures. In the initial samples, MK-CSA peaked at day 7. This preliminary data led to a prospective study of MK-CSA and clinical parameters in seven allogeneic recipients. MK-CSA activity increased from day -7 pre-transplant (2.9 +/- 1.7 CFU-MK/10(5) NATD, mean +/- SD) to day 0 (10.3 +/- 4.7 CFU-MK) and peaked by day 9 post-transplant (20.6 +/- 6.4 CFU-MK). MK-CSA activity decreased in all seven patients by day 21 at which time five of seven patients studied had recovery of platelet counts to greater than 100 x 10(9)/l. MK-CSA activity rose rapidly in both groups of sera after the initiation of this non-irradiation, BMT preparative regimen. High MK-CSA levels, early after transplant, may contribute to the rapid platelet recovery in some patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Busulfan,
http://linkedlifedata.com/resource/pubmed/chemical/Colony-Stimulating Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/mesothelin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
85
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
365-70
|
| pubmed:dateRevised |
2011-10-26
|
| pubmed:meshHeading |
pubmed-meshheading:8280609-Adult,
pubmed-meshheading:8280609-Bone Marrow Transplantation,
pubmed-meshheading:8280609-Busulfan,
pubmed-meshheading:8280609-Colony-Forming Units Assay,
pubmed-meshheading:8280609-Colony-Stimulating Factors,
pubmed-meshheading:8280609-Cyclophosphamide,
pubmed-meshheading:8280609-Female,
pubmed-meshheading:8280609-GPI-Linked Proteins,
pubmed-meshheading:8280609-Humans,
pubmed-meshheading:8280609-Male,
pubmed-meshheading:8280609-Megakaryocytes,
pubmed-meshheading:8280609-Membrane Glycoproteins,
pubmed-meshheading:8280609-Platelet Count,
pubmed-meshheading:8280609-Postoperative Period,
pubmed-meshheading:8280609-Prospective Studies,
pubmed-meshheading:8280609-Protein Biosynthesis,
pubmed-meshheading:8280609-Proteins,
pubmed-meshheading:8280609-Retrospective Studies
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Megakaryocyte colony stimulating activity in allogenic bone marrow recipients prepared with busulfan and cyclophosphamide.
|
| pubmed:affiliation |
Department of Pediatrics, Columbus Children's Hospital, Ohio State University.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|