Linked Life Data

8280485

Source:http://linkedlifedata.com/resource/pubmed/id/8280485

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1994-2-16
pubmed:abstractText
The tissue expression of carbohydrate antigen CA-242 was analysed in formalin-fixed biopsy specimens from 147 transitional cell bladder tumours. The staining was related to established prognostic factors and survival during a mean follow-up of over 12 years and the staining results were also compared to expression of CA-50 antigen. Forty-one percent (60/147) of the tumours were negative for CA-242 and 59% (87/147) were positive. Normal bladder mucosa was positive for CA-242 and the umbrella cells in particular showed intense positive staining. In tumours, the umbrella cells were usually positive (when present) and in tumour tissue, positive cells appeared either as individual positive cells or in groups. None of the tumours was entirely positive for CA-242. The tissue expression of CA-242 could not be significantly related to TNM classification, papillary status, WHO grade or quantitative variables (DNA ploidy, S phase fraction, mitotic frequency, nuclear factors). The tissue expression of CA-242 was significantly weaker than the expression of CA-50. The expression of CA-242 was related to favourable prognosis in survival analysis (P = 0.04). The results show that the expression of the novel tumour marker antigen CA-242 as determined in paraffin-embedded material is a weak prognostic factor as compared with established prognostic factors in transitional cell bladder tumours.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0959-8049
pubmed:author
pubmed:issnType
Print
pubmed:volume
29A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1935-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Expression of the tumour-associated antigen CA-242 in transitional cell bladder tumours: a comparison with CA-50.
pubmed:affiliation
Department of Pathology and Surgery, University of Kuopio, Finland.
pubmed:publicationType
Journal Article, Comparative Study