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rdf:type |
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lifeskim:mentions |
umls-concept:C0009325,
umls-concept:C0015127,
umls-concept:C0032174,
umls-concept:C0221464,
umls-concept:C0348080,
umls-concept:C0439831,
umls-concept:C0806140,
umls-concept:C1314792,
umls-concept:C1416496,
umls-concept:C1519726,
umls-concept:C1704657,
umls-concept:C1979845
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pubmed:dateCreated |
1994-2-7
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pubmed:abstractText |
Adhesion of human platelets to collagen under arterial flow conditions mediated by the alpha 2 beta 1 integrin increased tyrosine phosphorylation of several proteins, one of which was the focal adhesion tyrosine kinase, pp125FAK. Tyrosine phosphorylation of pp125FAK did not occur in non-adherent flowing platelets or in platelets attached to poly(L-lysine). Neither adhesion nor tyrosine phosphorylation was affected by pretreatment of platelets with GRGDSP peptide or by anti-alpha IIb beta 3 monoclonal antibody P2. Adherent platelets retained their discoid shape, suggesting that induction of pp125FAK precedes platelet spreading. The tyrosine kinase inhibitor erbstatin decreased tyrosine phosphorylation in non-stimulated platelets and blocked platelet adhesion. These results suggest that pp125FAK plays an important role in platelet adhesion to collagen via the alpha 2 beta 1 integrin.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1379699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1382425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1385444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1385445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1421580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1429685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-14731926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1555235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1594631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1629245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1631056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1650478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1691437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1691984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1702789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1715582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1717976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1725602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-1931088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2110361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2164806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2183161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2242040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2419901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2464741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2464830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2468666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2546619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2715183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2832397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-2928328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-3062626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-3106339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-6421308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-6815289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-7686553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-8340412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-8381117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8280049-8463210
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Protein-Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/PTK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
296 ( Pt 3)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
543-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8280049-Amino Acid Sequence,
pubmed-meshheading:8280049-Arteries,
pubmed-meshheading:8280049-Blood Circulation,
pubmed-meshheading:8280049-Blood Platelets,
pubmed-meshheading:8280049-Cell Adhesion,
pubmed-meshheading:8280049-Cell Adhesion Molecules,
pubmed-meshheading:8280049-Collagen,
pubmed-meshheading:8280049-Focal Adhesion Kinase 1,
pubmed-meshheading:8280049-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:8280049-Humans,
pubmed-meshheading:8280049-Integrins,
pubmed-meshheading:8280049-Microscopy, Electron, Scanning,
pubmed-meshheading:8280049-Molecular Sequence Data,
pubmed-meshheading:8280049-Phosphorylation,
pubmed-meshheading:8280049-Protein-Tyrosine Kinases,
pubmed-meshheading:8280049-Receptor, Insulin,
pubmed-meshheading:8280049-Tyrosine
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pubmed:year |
1993
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pubmed:articleTitle |
Platelet adhesion to collagen via the alpha 2 beta 1 integrin under arterial flow conditions causes rapid tyrosine phosphorylation of pp125FAK.
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pubmed:affiliation |
Department of Biochemistry, University of Virginia Health Science Centre, Charlottesville 22908.
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