Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1994-2-4
|
| pubmed:abstractText |
Serotyping and genotyping (polymerase chain reaction with sequence-specific oligonucleotide probes method) were conducted on 520 unrelated individuals to determine the linkage disequilibrium of HLA-B and HLA-DRB1. Analyses of 511 kidney transplants (300 related and 211 cadaver recipients) were carried out at 4 transplant centers using the linkage disequilibrium of HLA-B and HLA-DRB1 established previously. All transplant recipients received CsA immunosuppression and were transplanted from June 1983 to December 1991. There were 51 significant linkages formed between HLA-B and HLA-DRB1 alleles (P < 0.05). DRB1-compatible transplants experienced a comparable 5-year graft success rate of 94% as did the HLA-identical recipients with a 100% 5-year success rate. However DRB1-incompatible recipients displayed a significantly reduced 5-year graft survival rate of 73% (73% vs. 94% P < 0.01). The 5-year graft survival rate of HLA-DR-incompatible recipients of 71% was compatible to the 73% for HLA-DRB1-incompatible recipients. No variation of rejection rate for DRB1-compatible grafts was seen in any of the 4 transplant centers. The results also indicated that HLA-DRB1 compatibility was essential for optimal success rate, regardless of HLA class I mismatches. The overall conclusion was that matching for HLA-DR was important to achieve optimal kidney graft survival on the molecular level but not on the serotyping level.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0041-1337
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
1368-71
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8279004-Alleles,
pubmed-meshheading:8279004-Genotype,
pubmed-meshheading:8279004-Graft Rejection,
pubmed-meshheading:8279004-Graft Survival,
pubmed-meshheading:8279004-HLA-B Antigens,
pubmed-meshheading:8279004-HLA-DR Antigens,
pubmed-meshheading:8279004-HLA-DRB1 Chains,
pubmed-meshheading:8279004-Histocompatibility Antigens Class II,
pubmed-meshheading:8279004-Histocompatibility Testing,
pubmed-meshheading:8279004-Humans,
pubmed-meshheading:8279004-Kidney Transplantation,
pubmed-meshheading:8279004-Linkage Disequilibrium,
pubmed-meshheading:8279004-Polymerase Chain Reaction,
pubmed-meshheading:8279004-Prognosis,
pubmed-meshheading:8279004-Time Factors
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
The significant effect of HLA-DRB1 matching on long-term kidney graft outcome.
|
| pubmed:affiliation |
Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Japan.
|
| pubmed:publicationType |
Journal Article
|