Linked Life Data

827744

Source:http://linkedlifedata.com/resource/pubmed/id/827744

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1977-3-15
pubmed:abstractText
The mode of breakdown of sodium nitroprusside (NPN) is described and the fact is pointed out that cyanide is formed during the process. The main mode of detoxication leads to the production of thiocyanate. Potential effects of cyanide formation are: blocking of cytochrome oxidase and carbonic anhydrase and cyanmethaemoglobin. The clinical features of NPN poisoning are reviewed. The importance of preventing NPN poisoning by strictly adhering to the maximun doses (1.5mg/kg bodyweight) is emphasized. Anti-dose are; injections of hydroxycobalamin (22.4 mg/mg NPN) and sodium thiosulfate (5.0 mg/mg NPN). The use of drugs to induce methaemoglobin formation is now obsolete. As only very few cases of NPN poisoning have so far been reported; there is no need to discontinue the use of this drug, provided the maximun dosis is not exceeded and the patient is under strict surveillance.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0302-7600
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-96
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
[Toxicity of sodium nitroprusside (author's transl)].
pubmed:publicationType
Journal Article, English Abstract