Linked Life Data

8277001

Source:http://linkedlifedata.com/resource/pubmed/id/8277001

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-2-7
pubmed:abstractText
Studies of neonatal and adult mammals have shown that neuronal morphology is regulated in part by the availability of target-derived neurotrophic factor. To test whether the same is true for embryonic neurons, which are dependent on target-derived neurotrophic factors for survival, we grew neural crest-derived sensory neurons from the trigeminal ganglion of avian embryos of different ages in vitro in different concentrations of nerve growth factor (NGF) and measured the number of branch points and total length of the resulting arborizations. Although the size and complexity of arborizations increased with embryonic age up to embryonic day (E)14, neuronal morphology for embryos younger than E14 was unaffected by the concentration of NGF in the culture medium. However, beginning at E14, the stage at which trigeminal neurons start to lose their absolute requirement for NGF for survival, the neurons had significantly more branch points and larger arborizations in higher concentrations of NGF. Thus, it appears that the extent of neurite outgrowth in young embryos is independent of neurotrophic factor concentration; each neuron that receives enough neurotrophic factor to survive elaborates approximately the same size arbor. As trigeminal neurons mature and become less dependent on neurotrophic factor for survival, they acquire the ability to respond to neurotrophic factor with increased neurite growth and branching, as in neonates and adults.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
337
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-85
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Age-related effects of nerve growth factor on the morphology of embryonic sensory neurons in vitro.
pubmed:affiliation
Department of Anatomy, St. George's Hospital Medical School, Tooting, London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't