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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1994-2-4
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pubmed:abstractText |
Because of the nucleotide sequence diversity of different isolates of hepatitis C virus, it has become important to clarify whether distinct genotypes of hepatitis C virus vary with respect to pathogenicity, infectivity, response to antiviral therapy and geographic clustering. We assessed nucleotide sequence variability in the 5' noncoding region of hepatitis C virus, using restriction enzymes to analyze the distribution of hepatitis C virus genotypes, in 80 patients with chronic hepatitis C virus infection. Genotypes were correlated with demographic, clinical and histological features. Thirty-seven patients were infected with type 1, 10 had type 2 and 8 had type 3, and another 23 were infected with a new distinct hepatitis C virus type now classified as type 4. Two were infected with variants whose classification are uncertain. Types 1, 2 and 3 were found in patients from the United Kingdom, southern Europe, Asia, Africa and South America. Nineteen of 23 type 4 genotype isolates were from Middle Eastern patients, compared with 0 of 37 type 1 isolates (p < 0.001). Of 21 Middle Eastern patients, 19 (90.4%) had type 4 hepatitis C virus (p = 0.001, odds ratio = 9). We found no significant difference between the mean ages or mean serum aminotransferase concentrations between the various types. Types 1, 2, 3 and 4 were found in patients with mild-to-moderate disease or severe disease. However, 21 of 29 (72.4%) patients with type 1 who underwent liver biopsy had severe chronic hepatitis, cirrhosis or hepatocellular carcinoma histologically; 8 had mild or moderate chronic hepatitis without cirrhosis (p = 0.03, odds ratio = 2.6).(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-9139
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8276349-Adult,
pubmed-meshheading:8276349-Chronic Disease,
pubmed-meshheading:8276349-Cluster Analysis,
pubmed-meshheading:8276349-Egypt,
pubmed-meshheading:8276349-Europe,
pubmed-meshheading:8276349-Female,
pubmed-meshheading:8276349-Genotype,
pubmed-meshheading:8276349-Hepacivirus,
pubmed-meshheading:8276349-Hepatitis C,
pubmed-meshheading:8276349-Humans,
pubmed-meshheading:8276349-Interferon-alpha,
pubmed-meshheading:8276349-Male,
pubmed-meshheading:8276349-Middle Aged,
pubmed-meshheading:8276349-Middle East
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pubmed:year |
1994
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pubmed:articleTitle |
Hepatitis C virus genotypes: an investigation of type-specific differences in geographic origin and disease.
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pubmed:affiliation |
Department of Medicine, Royal Free Hospital and School of Medicine, London, United Kingdom.
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pubmed:publicationType |
Journal Article
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