Linked Life Data

8275821

Source:http://linkedlifedata.com/resource/pubmed/id/8275821

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1994-2-4
pubmed:abstractText
Renal osteodystrophy is a metabolic bone disease of chronic renal failure. The long-standing alterations in mineral metabolism generated by renal failure have a profound effect on the skeleton and induce severe systemic metabolic bone disease. Iliac crest biopsy was performed in 51 patients of chronic renal failure and examined with microscopy. The histological bone changes are characterized by ostitis fibrosa, increased resorption of bone and number of osteoclasts, increased osteoid volume (osteoblastic osteoid and acellular osteoid), active remodelling of bone and aluminum deposition in bone. According to the histological appearance, advanced renal bone disease can be subdivided into three major histological groups: secondly hyperparathyroid bone disease (high turnover uremic osteodystrophy), osteomalacia (low turnover uremic osteodystrophy) and mixed uremic osteodystrophy consisting of mild to moderate hyperparathyroid bone disease and defective mineralization. Aluminum-related bone changes can be seen in varying degrees in all these groups. Even though these groups do not fully represent separate entities and transformation from one form to another can occur, it is essential to distinguish them since therapy can be tailored according to the predominant histologic findings.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0578-1426
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
448-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[A pathological analysis of 51 cases of renal osteodystrophy].
pubmed:affiliation
Department of Pathology, Shanghai Second Medical University.
pubmed:publicationType
Journal Article, English Abstract