Linked Life Data

8275336

Source:http://linkedlifedata.com/resource/pubmed/id/8275336

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-2-10
pubmed:abstractText
In the adult rat, acute administration of cocaine results in enhanced expression of certain behaviors. This activation is often referred to as "stereotypy" because of its repetitive nature. Repeated exposure to the same dose of cocaine does not result in tolerance or a dimunition of these behavioral responses. Rather, an increased responsiveness to cocaine, termed "sensitization," is observed. Female rats, in comparison to male rats, display greater activation to a given dose of cocaine and greater sensitization with repeated exposure. As prenatal cocaine exposure can involve repeated exposure to the drug, we examined the behavioral activation induced by an acute dose of cocaine. Young adult rats of both sexes received a challenge dose of cocaine to determine the long-term effects of repeated in utero exposure to cocaine (30 mg/kg daily, SC) given between gestational days 8-20. As expected, female offspring of dams exposed to saline in utero displayed greater activation to a 20 mg/kg SC dosage of cocaine than their male counterparts. However, these sex differences were completely eliminated by prenatal exposure to cocaine. That is, female rats receiving cocaine during the prenatal period showed no more activation to an acute dose of cocaine as young adults than either control males or those males receiving cocaine in utero. Males exposed in utero to cocaine showed activation to cocaine challenge equivalent to that displayed by males exposed to saline in utero. Prenatal exposure to cocaine may alter sexual differentiation of the brain.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-82
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Prenatal cocaine eliminates the sex-dependent differences in activation observed in adult rats after cocaine challenge.
pubmed:affiliation
Neurotoxicology Division, Environmental Protection Agency, Research Triangle Park, NC 27711.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.