Linked Life Data

8274443

Source:http://linkedlifedata.com/resource/pubmed/id/8274443

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-6
pubmed:dateCreated
1994-2-7
pubmed:abstractText
Peroxisome proliferator activated receptors are ligand activated transcription factors belonging to the nuclear hormone receptor superfamily. Three cDNAs encoding such receptors have been isolated from Xenopus laevis (xPPAR alpha, beta, and gamma). Furthermore, the gene coding for xPPAR beta has been cloned, thus being the first member of this subfamily whose genomic organization has been solved. Functionally, xPPAR alpha as well as its mouse and rat homologs are thought to play an important role in lipid metabolism due to their ability to activate transcription of a reporter gene through the promoter of the acyl-CoA oxidase (ACO) gene. ACO catalyzes the rate limiting step in the peroxisomal beta-oxidation of fatty acids. Activation is achieved by the binding of xPPAR alpha on a regulatory element (DR1) found in the promoter region of this gene, xPPAR beta and gamma are also able to recognize the same type of element and are, as PPAR alpha, able to form heterodimers with retinoid X receptor. All three xPPARs appear to be activated by synthetic peroxisome proliferators as well as by naturally occurring fatty acids, suggesting that a common mode of action exists for all the members of this subfamily of nuclear hormone receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0960-0760
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-73
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:8274443-Acyl-CoA Oxidase, pubmed-meshheading:8274443-Amino Acid Sequence, pubmed-meshheading:8274443-Animals, pubmed-meshheading:8274443-Base Sequence, pubmed-meshheading:8274443-Cloning, Molecular, pubmed-meshheading:8274443-DNA, Complementary, pubmed-meshheading:8274443-Fatty Acids, pubmed-meshheading:8274443-Introns, pubmed-meshheading:8274443-Macromolecular Substances, pubmed-meshheading:8274443-Molecular Sequence Data, pubmed-meshheading:8274443-Oxidoreductases, pubmed-meshheading:8274443-Promoter Regions, Genetic, pubmed-meshheading:8274443-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:8274443-Receptors, Retinoic Acid, pubmed-meshheading:8274443-Retinoid X Receptors, pubmed-meshheading:8274443-Transcription Factors, pubmed-meshheading:8274443-Xenopus laevis
pubmed:year
1993
pubmed:articleTitle
Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids.
pubmed:affiliation
Institut de Biologie Animale, Université de Lausanne, Bâtiment de Biologie, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't