Linked Life Data

8274304

Source:http://linkedlifedata.com/resource/pubmed/id/8274304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-2-8
pubmed:abstractText
Although bone formation is coupled to resorption in both man and the rat, it is not known whether similar mechanisms are involved in these two species. To investigate this, we have attempted to further characterise the suppression of bone formation by the potent bone resorption inhibitor 3-amino-1-hydroxypropylidine-1-bisphosphonate (AHPrBP) in ovariectomised adult female rats. To see whether AHPrBP affects the activity of preexisting bone forming surfaces, as opposed to preventing the induction of new forming surfaces, three consecutive fluorochrome labels were administered 3, 10, and 17 days prior to sacrifice. The percentage of trabecular surface covered by first and second labels only (arrested surface), second and third labels only (induction surface), and all three labels (persisting surface) were recorded at the secondary spongiosa of the proximal tibial metaphysis. As expected, ovariectomy increased the proportion of induction surfaces, with AHPrBP preventing this increase. However, AHPrBP also reduced the proportion of persisting surfaces, implying inhibition of the activity of preexisting bone-forming surfaces. We conclude that resorption inhibitors such as AHPrBP inhibit bone formation in the rat in a manner which appears inconsistent with the site-specific coupling seen in the adult human skeleton.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
8756-3282
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
619-23
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:articleTitle
3-Amino-1-hydroxypropylidine-1-bisphosphonate (AHPrBP) suppresses not only the induction of new, but also the persistence of existing bone-forming surfaces in rat cancellous bone.
pubmed:affiliation
Department of Histopathology, St. George's Hospital Medical School, London, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't