Linked Life Data

8268754

Source:http://linkedlifedata.com/resource/pubmed/id/8268754

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-2-2
pubmed:abstractText
In vitro studies indicate that transforming growth factor-beta (TGF-beta) has a role in the regulation of bone cell activities. However, little is known about the effects of TGF-beta on bone when it is administered systemically. This study was undertaken to evaluate the in vivo effects of TGF-beta 2 on bone and marrow cells in the ovariectomized rat bone loss model. Female Sprague-Dawley rats, aged 95 days, were divided into 4 groups. Group 1 was sham operated; groups 2-4 were ovariectomized. Groups 3 and 4 received daily injections of 10 micrograms and 50 micrograms of TGF-beta 2/kg body weight, respectively. Groups 1 and 2 received the solvent vehicle. All animals were sacrificed after 35 days. Ovariectomy caused a significant increase in, total mononuclear marrow cells, the number of TRAP positive multinucleated cells formed in culture of marrow cells, and the number of trabecular osteoclasts and osteoblasts. These increases were associated with loss of cancellous bone in the proximal tibia. TGF-beta 2 completely prevented the increase in the number of TRAP positive multinucleated cells, and caused a small but not statistically significant decrease in the number of trabecular osteoclasts. However, TGF-beta 2 had no significant effect on the number of total mononuclear marrow cells and on the loss of cancellous bone due to ovariectomy. We conclude that TGF-beta 2 probably plays a role in the regulation of the proliferation of osteoclast progenitors in bone marrow in vivo. Studies carried out over a longer period are required to determine whether it will modulate the increase in osteoclast and osteoblast numbers that occur in cancellous bone following ovariectomy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0169-6009
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
In vivo effects of transforming growth factor-beta 2 in ovariectomized rats.
pubmed:affiliation
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.