Linked Life Data

8268244

Source:http://linkedlifedata.com/resource/pubmed/id/8268244

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-1-28
pubmed:abstractText
The present work aimed to further characterise the hepatic alpha 1-adrenergic actions by studying the influence of nutritional status and/or extracellular medium composition in the alpha 1-adrenoceptor-induced responses. The experiments were performed in a non-recirculating liver-perfusion system featuring continuous monitoring of vascular resistance, as well as the effluent perfusate changes in pO2, pCa2+, pK+ and pH. The alpha 1-adrenoceptor activation produced biphasic responses to most parameters studied. The acute phase lasted for about 3 min and it was followed by a phase of sustained stimulation that lasted as long as the receptor activation was maintained. Our data indicate that there is not a single pattern of alpha 1-adrenergic responses but variable patterns depending on the nutritional status and the experimental conditions. Gluconeogenic substrates alone produced reciprocal changes in the outflow perfusate pH and Ca2+ activity. The magnitude of these changes indicates that the diversity of alpha 1-adrenoceptor responses are the result of the superposed effects of different rates of substrates and/or metabolites transport. The sustained alpha 1-adrenoceptor stimulation produced extracellular acidification and increases in respiration, vascular resistance and Ca2+ release. These responses required physiological extracellular [Ca2+]. At low extracellular [Ca2+], the alpha 1-adrenoceptor activation failed to acidify the extracellular medium, suggesting that receptor-induced H+ efflux demands normal rates of Ca2+ influx. The correlation between alpha 1-adrenergic-induced increase in O2 uptake and Ca2+ release indicates that the increased energy production can be accounted for by the energy cost of Ca2+ release. The alpha 1-agonist concentration-response studies have shown significant differences in the [alpha 1-agonist]0.5 for each type of response, suggesting the existence of multiple alpha 1-adrenoceptor-coupled signal-transduction pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
1220
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Characterization of the alpha 1-adrenoceptor-mediated responses in perfused rat liver.
pubmed:affiliation
Endocrine Physiology Unit, Centro de Investigaciones Biológicas, C.S.I.C., Madrid, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't