Linked Life Data

8267187

Source:http://linkedlifedata.com/resource/pubmed/id/8267187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-1-25
pubmed:abstractText
The effect of nimodipine on organ blood flow during cardiopulmonary resuscitation (CPR) was studied in 26 anesthetized pigs. After 5 min of ventricular fibrillation circulatory arrest and 5 min of external CPR, all animals received 50 micrograms/kg of epinephrine and either nimodipine (10 micrograms/kg, followed by 1 microgram.kg-1.min-1 until termination of the experiment) or placebo. Organ blood flow was measured using radioactive-labeled microspheres. The rate of resuscitability in nimodipine-treated pigs (11 of 12) was significantly higher (P < 0.05) than in placebo-treated animals (7 of 14). In pigs receiving epinephrine and nimodipine, left ventricular blood flow after restoration of spontaneous circulation (ROSC) was approximately twice as high as in pigs receiving epinephrine and placebo (P < 0.01). In nimodipine-treated pigs, total cerebral blood flow 10 min after ROSC was significantly higher than baseline values (P < 0.01) and in hypophysis, cerebellum, and medulla the blood flows were significantly higher than in placebo-treated pigs (P < 0.05). We conclude that, in our pig model, high doses of nimodipine given during CPR caused significant enhancements in left ventricular blood flow and significantly improved the rate of resuscitation.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-93
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effects of nimodipine on regional blood flow in heart and brain during cardiopulmonary resuscitation in pigs.
pubmed:affiliation
Department of Anesthesia and General Intensive Care Medicine, University of Vienna, Austria.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't