Linked Life Data

8265736

Source:http://linkedlifedata.com/resource/pubmed/id/8265736

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1994-1-27
pubmed:abstractText
Stress elicits activation of the hypothalamic-pituitary-adrenocortical (HPA) axis. Hypothalamic neurohormones, including corticotropin-releasing factor (CRF), control and promote ACTH secretion and subsequent glucocorticoid synthesis and release. The neonatal rat has been shown to be relatively hyporesponsive to certain stressors, generating a blunted or unmeasurable hormonal response. In this study, the endocrine response of 10- and 18-day-old Sprague-Dawley rat pups to maternal separation, a naturalistic stressor, was examined. Ten-day pups subjected to maternal separation exhibited a significant reduction in median eminence CRF concentration at 24 h, with no change in pituitary CRF receptor number; in 18-day pups there was no significant change in median eminence CRF concentration by 24 h, but there was a decrease in CRF receptor binding. In adult rats subjected to stressors, an acute decrease in CRF concentration in the median eminence occurs, followed by CRF receptor downregulation with sustained stress. The results observed in the 18-day pups vs. the 10-day pups likely reflects a maturation of the HPA axis response to "stressors."
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4530
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
485-93
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor.
pubmed:affiliation
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't